The Mandrake takes place over a 24-hour period. The protagonist, Callimaco, desires to sleep with Lucrezia, the young and beautiful wife of an elderly fool, Nicia. Nicia above all else desires a son and heir, but still has none. Conspiring with both Ligurio, a rascally marriage broker, and a corrupt priest named Friar Timoteo, Callimaco masquerades as a doctor. He convinces Nicia to drug Lucrezia with mandrake, claiming it will increase her fertility. He adds, however, the dire warning that the mandrake will undoubtedly kill the first man to have intercourse with her. Ligurio helpfully suggests to Nicia that an unwitting fool be found for this purpose. A reluctant Lucrezia is eventually convinced by her mother and the priest to comply with her husband’s wishes. She allows a disguised Callimaco into her bed and, believing that the events which caused her to break her marriage vows were due to divine providence, thereafter accepts him as her lover on a more permanent basis.